Management of Acute Appendicitis during COVID-19 Pandemic in a Tertiary Care Centre: A Descriptive Cross-sectional Study

ABSTRACT Introduction: Acute appendicitis is the most common reason for abdominal surgery in children. Though appendectomy considered the gold standard there are a lot of complications related to it. Conservative management of acute appendicitis is not new to medical science. In pandemic like COVID-19 when all the health systems were about to shut-down because of lack of manpower and resources, we started a trial of non-operative management. The main aim of this study is to find out the management of acute appendicitis during COVID-19. Methods: This was a descriptive cross-sectional study conducted in a tertiary care centre. Data collection was done from the record section which included the patients diagnosed with acute appendicitis from February 2020 to July 2020 after obtaining ethical clearance from Institutional Review Committee. Cases of appendicular lump, appendicular abscess, appendicular perforations have been excluded. Data was collected and entry was done in Statistical Package for the Social Science software version 20, point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Results: The conservative management of acute appendicitis was done in 44 cases (55.7%) while 35 cases (44.3%) had to undergo appendectomy. Conclusions: COVID-19 can complicate the perioperative course as a result of direct lung injury and multiple organ dysfunctions and can also bring serious threats to the safety of medical staffs involved in managing the acute appendicitis case operatively, so conservative management can be considered as an alternative way of management of acute appendicitis in the pandemic outbreak.


INTRODUCTION
Acute appendicitis (AA) is the leading reason for abdominal surgery in children. [1][2][3] Based upon assumption that AA is irreversible progressive disease, leading to perforation of appendix with subsequent peritonitis, appendectomy is considered as gold standard. 4 Although curative, appendectomy is invasive procedure requiring general anesthesia with associated perioperative risks and postoperative complications in about 10% within 30 postoperative days. 5,6 Non-operative management (NOM) of AA, with multiple reported case series of successful treatment of soldiers during wartime or submariners during long missions. 7 During COVID-19 outbreak, there has been a renewed interest in managing patients with AA nonoperatively with antibiotics, thereby reducing the amount of theatre time, staff time and surgical resources. 1,7,8 Also, patients with the COVID-19 have substantially higher operative risks due to the compromisation of lung function and the cytokine storms that result in systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction. 9 The main aim of this study is to find out the management of acute appendicitis during COVID-19.

METHODS
This was a descriptive cross-sectional study conducted Management of Acute Appendicitis during COVID-19 Pandemic in a Tertiary Care Centre: A Descriptive Cross-sectional Study Free Full Text Articles are Available at www.jnma.com.np in Kanti Children's Hospital. Ethical clearance was obtained from Institutional review committee -KCH. Data of the patients diagnosed as AA from February 2020 to July 2020 was collected and the age, sex, days of hospitalization, total leukocyte count, lumen diameter, management process, symptoms and signs were analyzed. Cases of appendicular lump, appendicular abscess, appendicular perforation have been excluded. Those patients who didn't respond to antibiotics i.e. no decrease in MANTRELS score from time of admission within 24 hours were operated and the follow-up data of the case undergoing NOM was also analyzed. Sample size was calculated using the formula; n= Z 2 x p x q / e 2 = (1.96) 2 x (0.`5) x (1-0.5) / (0.11) 2 = 79 Where, n= required sample size, Z= 1.96 at 95% Confidence Interval p= prevalence of conservative management in patients of acute appendicitis, 50% q= 1-p e= margin of error, 11% As a part of NOM, patients were kept nil per oral and supplemented with intravenous fluids in maintenance dose, intravenous antibiotics cefotaxime 50 mg/kg body weight/dose thrice daily, metronidazole 7.5-15mg/kg body weight/dose thrice daily, tobramycin 2-2.5mg/kg body weight/dose twice daily, intravenous analgesic ketorolac 0.5mg/kg body weight/dose thrice daily. The antibiotic cefotaxime was upgraded within 24-48 hours of its 1 st dose, to Piperacillin + Tazobactam combination 90 mg/kg body weight/dose thrice daily in the case in which there is only minimal subsidence of signs and symptoms, i.e. only decrease in MANTRELS score by 1-3 points from the score at the time of admission. However, decrease in score by ≥4 points were continued the same antibiotics.
The data was entered in MS excel program 2013 and necessary descriptive statistics were obtained using SPSS version 20.

RESULTS
Among seventy-nine cases of AA 44 cases (55.7%) were managed conservatively, and 35 cases (44.3%) undergone appendectomy because of persistence of signs and symptoms of same intensity as presented to emergency department even after supplemented with the IV antibiotics, IV analgesics and i.v fluid within 24 hours (Figure 1).

Figure 1. Distribution of management of acute appendicitis.
Among the 79 cases of AA, 55 cases (70%) were male, and 24 cases (30%) were female ( Figure 2). The mean age of the patients of AA was found to be 8.81±3.38 years and the mean of white blood cell count in patients of AA was found to be 14140.25±2333.33 cells/mm 3 . Abdominal sonography was done in all cases but the appendix was not visualized in 33 cases and in the remaining 46 cases the mean lumen size was 7.97±2.09 cm. The mean days of hospitalization of patients of AA were found to be 4.46±1.89 days (Table  1). The most common clinical presentation of patients with AA was found to be a pain in the right iliac fossa 79 (100%), followed by nausea 78 (98.7%) and vomiting 61 (77.2%). Fever and rebound tenderness was seen in only 37 (46.8%) and 33 (41.8%) respectively (Table 2).  In our study, we used cefotaxime, tobramycin, and metronidazole. If the patient's condition were improving and were tolerating oral, then we had switched to oral antibiotics and discharged the patient. But if the patient was improving partially within 24 to 48 hours, then we had counselled the patient party before upgrading antibiotics to piperacillin and tazobactam combination and observing the patient. If the child's condition was not improving at all, then we proceeded with appendectomy.
NOM for AA is less invasive and has less morbidity related with surgery and anesthesia, but is associated with failure of management and the risks of relapses. Study done by Mudri et al. shows that recurrence rate of NOM of AA is 21%, during one year follow up. 25 In our study, the recurrence rate for NOM is difficult to assess due to quite short follow up i.e. 2 nd and 6 th week of discharge.
There are no as such studies that describe this trend in more detail, so more study need to be done to find out the management in AA during pandemic outbreak. Our study has reflected the case of AA of short time period, i.e. only six months duration. In addition, we have only information that had been documented and accessible in our medical records. Hence our study have some limitations and lacks external validity.
Free Full Text Articles are Available at www.jnma.com.np CONCLUSIONS COVID-19 patients may have high postoperative mortality, and postoperative respiratory complications. Medical staff serving operative patients is at high risks of cross-infection. Thus, NOM of AA may be an alternative choice of treatment during the pandemic outbreaks like COVID-19. However, an optimal selection of antibiotics and a close observation of the medical person is required. Besides that, the chance of readmission is quite high, which needs further research and long term follow up to decide the wellbeing and benefits of broad spectrum antibiotics versus an appendectomy.