Prevalence of Hemolysis, Elevated Liver Enzymes, Low Platelet Count Syndrome in Pregnant Women in a Tertiary Care Hospital

  • Sarita Sitaula Department of Obstetrics and Gynecology, BP Koirala Institute of Health Sciences, Dharan, Nepal.
  • Tara Manandhar Department of Obstetrics and Gynecology, BP Koirala Institute of Health Sciences, Dharan, Nepal.
  • Baburam Dixit Thapa Department of Obstetrics and Gynecology, BP Koirala Institute of Health Sciences, Dharan, Nepal.
  • Ramesh Shrestha Department of Obstetrics and Gynecology, BP Koirala Institute of Health Sciences, Dharan, Nepal.
  • Dinesh Dharel Department of Pediatrics and Department of Community Health and Epidemiology, University of Saskatchewan, Canada.
Keywords: cesarean section; HELLP syndrome; maternal mortality.

Abstract

Introduction: Hemolysis, Elevated Liver Enzymes, Low Platelet count syndrome refers to biological syndrome occurring in pre-eclamptic and eclamptic women. There is a higher rate of maternal and perinatal morbidity and mortality due to the syndrome. So, the objective of the study is to find the prevalence and maternal- perinatal outcome in the syndrome.


Methods: A descriptive cross-sectional study was done in a tertiary care hospital from 1st April 2017 to 30th March 2018 after obtaining ethical clearance from the Institutional Review Committee. The inclusion criteria were patients giving consent for participation and those who delivered in our hospital. Patient with the syndrome who delivered outside and referred in the postpartum period was excluded because details of the neonate may not be available. The Statistical Package for Social Sciences version 21 was used for the analysis of the data. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.


Results: Out of 11974 deliveries, the prevalence of Hemolysis, Elevated Liver Enzymes, Low Platelet count syndrome was 83 (0.69%) at 95% Confidence Interval (59.06-78.94). Maternal complications were seen in 19 (22.9%) and common complications being acute renal failure 9 (47.37%) followed by postpartum hemorrhage 4 (21.05%). Nearly 27 (33%) of patients required maternal ICU stay and there was one maternal mortality.


Conclusions: Hemolysis, Elevated Liver Enzymes, Low Platelet count syndrome is one of the major causes of maternal and perinatal morbidity and mortality. Hence early recognition and prompt management may improve maternal and fetal outcomes.

Published
2020-06-30
How to Cite
Sitaula, S., Manandhar, T., Dixit Thapa, B., Shrestha, R., & Dharel, D. (2020). Prevalence of Hemolysis, Elevated Liver Enzymes, Low Platelet Count Syndrome in Pregnant Women in a Tertiary Care Hospital. Journal of Nepal Medical Association, 58(226). https://doi.org/10.31729/jnma.4921