TY - JOUR AU - Regmi, Kiran AU - Shrestha, Jeetndra Kaji AU - KC, Sudhamshu AU - Jaishi, Bikash AU - Karki, Niyanta AU - Khadka, Dipendra AU - Khadka, Sandip PY - 2017/12/31 Y2 - 2024/03/29 TI - Prevalence of Hepatitis D Among Patients with Hepatitis B Viral Infection Attending a Tertiary Care Centre of Nepal JF - Journal of Nepal Medical Association JA - J Nepal Med Assoc VL - 56 IS - 208 SE - Original Article DO - 10.31729/jnma.3378 UR - http://www.jnma.com.np/jnma/index.php/jnma/article/view/3378 SP - 417-20 AB - <p class="p1"><span class="s1"><strong>Introduction: </strong></span>Worldwide there is variation in prevalence of Hepatitis D viral infection. Superinfection and co infection with hepatitis B viral infection is known to occur in 15-20 million people.</p><p class="p1"><span class="s1"><strong>Methods: </strong></span>This was a descriptive cross-sectional hospital based study carried out in NAMS, Bir hospital, Kathmandu, Nepal from period of January 2017 to June 2017. Consecutive patients of chronic hepatitis B viral infection of HBsAg positive with more than two-time upper normal limit of ALT were enrolled and tested for HDV IgG.</p><p class="p1"><span class="s1"><strong>Results:</strong></span> Forty patients were enrolled during study period. Mean age was 30.9±12.2 years. Males were 28 (70%) and females 12 (30%). Most of the patients were asymptomatic for HBV infection 32 (80%). HBeAg negative chronic hepatitis was most commonly present in 31 (77.5%). Family history of Hepatitis B viral infection was seen in 7 (17.5%) and sexual promiscuity in 5 (12.5%) as the mode of acquisition of hepatitis B viral infection. HBcIgM was positive in three patients with mean HBV DNA of 4.97x10<sup>5</sup>±4.5x10<sup>5 </sup>IU/ml in HBeAg positive group. HDV IgG was negative in all patients.</p><p class="p1"><span class="s1"><strong>Conclusions:</strong></span> Coinfection and superinfection of hepatitis D virus were found to be uncommon at Bir hospital, Nepal.</p><p class="p2"><span class="s2"><strong>Keywords:</strong></span><em> HbsAg; HDV DNA; HDV IgG; Hepatitis B; Hepatitis D. </em></p> ER -