Sleep Induced Hypoxemia in Chronic Obstructive Pulmonary Disease

  • Jing Zhang Respiratory Department of Tianjin Medical University General Hospital, Tianjin 300052, China
  • Yan Wang Respiratory Department of Tianjin Medical University General Hospital, Tianjin 300052, China
  • Jing Feng Respiratory Department of Tianjin Medical University General Hospital, Tianjin 300052, China
  • Xin Sun Respiratory Department of Tianjin Haihe Hospital, Tianjin 300350, China

Abstract

Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality worldwide.
Sleep-induced hypoxemia is defined as “an SpO2 (oxyhemoglobin saturation) during sleep of <
90% for more than five minutes with a nadir of at least 85%” or “> 30% of total sleep time with an
SpO2 of < 90%” in subject with a baseline awake SpO2 of ≥ 90%. Patients with moderate or severe
COPD run a high risk of developing SIH mainly because of alveolar hypoventilation and ventilationperfusion
mismatch. Compared to their non-SIH brethren, SIH COPD patients have greater degrees
of pulmonary hypertension and cor pulmonale, require more frequent hospitalizations, and sustain
higher mortality rates. And the necessity of treatment of isolated SIH in COPD has been debated
for years. In this mini review, the definition, reasons, prevalence, clinical significance and treatment
approaches of SIH in COPD are summarized.
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Keywords: chronic obstructive pulmonary disease; polysomnography; rapid eye movement;
sleep-induced hypoxemia.

Published
2013-07-01
How to Cite
Zhang, J., Wang, Y., Feng, J., & Sun, X. (2013). Sleep Induced Hypoxemia in Chronic Obstructive Pulmonary Disease. Journal of Nepal Medical Association, 52(191). https://doi.org/10.31729/jnma.2285
Section
Review Article