An Interesting Case of Basal Cell Carcinoma with Raynaud’s Phenomenon Following Chronic Arsenic Exposure

Authors

  • Shazia Gulshan Department of Pathology, NRS Medical College, Kolkata, India
  • Muhammed Jawaid Rahman Department of Urology, Regional Institute of Medical sciences, Imphal, India
  • Ranu Sarkar Department of Pathology, NRS Medical College, Kolkata, India
  • Suman Ghosh Department of Pathology, NRS Medical College, Kolkata, India
  • Rathin Hazra Department of Pathology, NRS Medical College, Kolkata, India

DOI:

https://doi.org/10.31729/jnma.2592

Keywords:

basal cell carcinoma; chronic arsenic exposure; raynaud’s phenomenon.

Abstract

Arsenic is commonly known to be associated with squamous cell carcinoma. Among the lesser known associations is basal cell carcinoma and even rarer is its effect on blood vessels causing peripheral vascular disease. Here we present a case of a 55 yr old man with ulceroproliferative lesions on scalp and forehead along with several hyperpigmented patches on trunk and extremities. He had symptoms suggestive of Raynaud’s phenomenon that eventually led to digital gangrene. FNAC was done which was suggestive of basal cell carcinoma. On further enquiry, he was found to reside in an arsenic endemic zone and was investigated for blood arsenic level which was elevated. Punch biopsy from different lesions from body confirmed nodular basal cell carcinoma. Presently the patient has stopped drinking water from the local tubewell. On follow-up he shows improvement of Raynaud’s phenomenon and skin lesions.

Keywords: basal cell carcinoma; chronic arsenic exposure; raynaud’s phenomenon. | PubMed

Author Biography

Shazia Gulshan, Department of Pathology, NRS Medical College, Kolkata, India

Pathology, Resident

References

1. Yu HS, Liao WT, Chai CY; Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. dermyu@ha.mc.ntu.edu.tw
2. Wong SS, Tan KC, Goh CL. ; National Skin Centre ,Singapore.
3. Jose A Centeno, Florabel G Mullick, Leonor Martinez, Norbert P Page, Herman Gibb, David Longfellow, Claudia Thompson, and Elena R Ladich Division of Biophysical Toxicology, U.S. Armed Forces Institute of Pathology, Washington, DC 20306-6000
4. Shun-Long Chen, Shlaan I?. Dzeng, and Mo-Hslung Yang', Institute of Nuclear Science, National Tsing Hua University, Hsinchu, Taiwan, Republic of China ; Kong-Hwa Chlu, Guan-Mlng Shleh, and Chlen M.Wai' Department of Chemistry, University of Idaho, Moscow, Idaho, 83843.
5. Elder, David E.; Elenitsas, Rosalie; Johnson, Bernett L.; Murphy, George F: Lever's Histopathology of the Skin, 9th Edition.

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Published

2016-12-23

How to Cite

Gulshan, S., Rahman, M. J., Sarkar, R., Ghosh, S., & Hazra, R. (2016). An Interesting Case of Basal Cell Carcinoma with Raynaud’s Phenomenon Following Chronic Arsenic Exposure. Journal of Nepal Medical Association, 55(204), 100–102. https://doi.org/10.31729/jnma.2592

Issue

Vol. 55 No. 204 (2016)

Section

Case Reports

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