Role of Biochemical Investigation in Prediction of Biliary Etiology in Acute Pancreatitis

  • Tanka Prasad Bohara Kathmandu Medical College Teaching Hospital
  • Anuj Parajuli Kathmandu Medical College Teaching Hospital
  • Mukund Raj Joshi Kathmandu Medical College Teaching Hospital


Introduction: Acute pancreatitis is common clinical resentation. Gall stone disease and alcohol consumption are most common etiologies. Detection of biliary etiology is important in order to provide definite management in form of cholecystectomy to prevent further attacks. Sensitivity 
for abdominal ultrasound to detect cholelithiasis is decreased to 67–87% in presence of acute pancreatitis. Difference in biochemical investigations of acute biliary and non-biliary pancreatitis has been proposed to increase the suspicion of biliary etiology.

Methods: Sixty patients admitted with diagnosis of acute pancreatitis from March 2012 to December 2012 were included in the study. The relation between etiology with age, sex, admission serum amylase and liver function test were evaluated.

Results: Out of 60 patients 38 (63.33%) and 22 (36.66%) had biliary and non-biliary etiology respectively. Biliary pancreatitis was more common in females (25 vs. 3). Distribution of severity was comparable between both groups. Biliary pancreatitis group had significantly higher amylase level (3466.42 vs. 1987.5, p 0.003) whereas values of liver function test were higher in biliary pancreatitis 
though not statistically significant.

Conclusions: A simple, rapid and accurate prediction of biliary etiology of acute pancreatitis can be provided by changes in biochemical parameters.

Keywords: Acute Pancreatitis; Biliary Pancreatitis; Serum Amylase.  

Author Biographies

Tanka Prasad Bohara, Kathmandu Medical College Teaching Hospital
Anuj Parajuli, Kathmandu Medical College Teaching Hospital
Mukund Raj Joshi, Kathmandu Medical College Teaching Hospital
Associate Professor


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How to Cite
Bohara, T., Parajuli, A., & Joshi, M. (2013). Role of Biochemical Investigation in Prediction of Biliary Etiology in Acute Pancreatitis. Journal of Nepal Medical Association, 52(189), 229-232.
Original Article

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