Markers of Autolysis in Acute ST Elevation Myocardial Infarction – A Comparative Analysis

Authors

  • Prabindra Maharjan Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.
  • Reezu Manandhar Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.
  • Wei Xu Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.
  • Shuting Ma Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.
  • Wenqi Han Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.
  • Yan Liu Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.
  • Yuan Zhou Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.
  • Yue Wu Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.
  • Caofeng Sun Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.
  • Zuyi Yuan Department of Cardiovascular Unit, First Affiliated Hospital of Xi’an Jiao Tong University School of Medicine, Xi’an, Shaanxi, China.

DOI:

https://doi.org/10.31729/jnma.2769

Keywords:

acute coronary syndrome; infarct related artery; myocardial infarction.

Abstract

Introduction: The availability of reliable noninvasive markers for infarct-related artery patency status are very limited, otherwise could allow early identification of patients with patent IRA, for whom repeat thrombolysis or rescue percutaneous coronary intervention are not necessary.

Methods: We conducted a single centered retrospective study of STEMI patients undergoing primary PCI to determine how various factors such as demographic characteristics, risk markers of coronary heart disease, clinical and blood parameters present differently in patients with higher coronary flow and patent infarct related artery from patients with total occlusion at the time of initial angiography and how they affect in outcome of the disease.

Results: MPV level (11.96 fL vs. 10.92 fL, P < 0.001), Lp (a) level (179.57 nmol/l vs 141.16 nmol/l , p < 0.001), CK-MB (290.2 vs. 190.98, P < 0.001), total cholesterol level (4.11 mmol/L vs. 3.8 mmol/L, p < 0.02) in total occlusion group were higher than in the patent IRA group. Wall motion abnormality was 77.2% for 203 patients with total occlusion group and 54.2% for 83 patients with patent IRA group (P<0.01). Mean hospital stay days were higher in total occlusion group as compared to the patent IRA group P < 0.01.

Conclusions: MVP, Lp (a), TC, and CK-MB levels and myocardial wall motion at the presentation may play the role of markers for IRA patency status that will help in early identification of patients with IRA, for whom repeat thrombolysis or rescue PCI may not be required. 

Keywords: acute coronary syndrome; infarct related artery; myocardial infarction.

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Published

2015-06-30

How to Cite

Maharjan, P., Manandhar, R., Xu, W., Ma, S., Han, W., Liu, Y., Zhou, Y., Wu, Y., Sun, C., & Yuan, Z. (2015). Markers of Autolysis in Acute ST Elevation Myocardial Infarction – A Comparative Analysis. Journal of Nepal Medical Association, 53(198), 96–103. https://doi.org/10.31729/jnma.2769

Issue

Vol. 53 No. 198 (2015)

Section

Original Article

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