Hormonal Changes in Intracranial Hemorrhage

  • Rajendra Shrestha department of Neurosurgery,NAMS, Bir Hospital/ National Trauma Centre
  • Reeka Pradhan Paropkar maternity and women’s Hospital, Thapathali, Nepal
  • Mahesh Pradhan Department of Surgery, Sumeru Hospital, Nepal
  • Chao You Department of Neurosurgery, West China Hospital, Sichuan University, China.
Keywords: ACTH; ICH; lymphocyte ICH; thyroid hormone.


Introduction: The purpose of this study was to investigate the changes of serum ACTH and Thyroid hormone level in the acute phase of ICH.

Methods: Sixty patients with spontaneous ICH were assessed regarding hormonal changes by measuring ACTH and Thyroid hormone level. The relationships of hormone concentrations to clinical and radiological parameters were evaluated at hospital admission (t0), 5 days (t1) and 10 days (t2). The results were statistically analyzed.

Results: ACTH, TSH, Thyroxine, and free Thyroxine were not significantly different among the three time periods (P > 0.05), while Triiodothyronine (T3) and free Triiodothyronine (FT3) were significantly different (P < 0.05). T3 and FT3 were not significantly different among patients with hemorrhage of different locations (P>0.05). There were significant negative correlations between T3 and FT3 with volume of ICH (r=-0.63 and r=-0.25) and there were positive correlations between T3 and FT3 with GCS (r=0.63 and r=0.37) respectively on admission day (p <0.05).

Conclusions: Hormonal secretion patterns is associated with the severity of ICH. This is an important index to evaluate the disease severity and prognosis.

Keywords: ACTH; ICH; lymphocyte ICH; Thyroid hormone.


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How to Cite
Shrestha, R., Pradhan, R., Pradhan, M., & You, C. (2017). Hormonal Changes in Intracranial Hemorrhage. Journal of Nepal Medical Association, 56(205), 163-167. https://doi.org/10.31729/jnma.3026
Original Article