Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women

  • Bikram Khadka Department of Biochemistry, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.
  • Mohan Lal Tiwari Department of  Internal Medicine, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.
  • Ravi Gautam Department of Occupational Health, College of Bio-Medical Sciences, Daegu Catholic University, Gyeongsan 38430, Korea.
  • Binod Timalsina Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.
  • Nandu Prasad Pathak Internal Medicine, Lumbini Zonal Hospital, Rupandehi, Butwal, Nepal.
  • Krishna Kharel Department of Orthopedic Surgery, Tilottama Hospital, Rupandehi, Butwal, Nepal.
  • Shanta Sharma Deapartment of Community Medicine, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.
  • Dilaram Acharya Department of Community Medicine, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.

Abstract

Introduction: Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important of research in low income country like Nepal. 

Methods: A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20.

Results: Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01).

Conclusions: Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health.

Published
2018-08-31
How to Cite
Khadka, B., Tiwari, M., Gautam, R., Timalsina, B., Pathak, N., Kharel, K., Sharma, S., & Acharya, D. (2018). Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women. Journal of Nepal Medical Association, 56(212), 754-758. https://doi.org/10.31729/jnma.3604
Section
Original Article