association of liPid Profile and body Mass index (bMi) in HyPertensive Patients of eastern nePal

Abstract

Dyslipidemia is closely associated with hypertension. Out of different fractions of lipoprotein, definite
association of elevated LDL-Cholesterol (LDLc) and other lipid parameters has been well observed
in hypertensive patients. The present cross sectional study was undertaken at BP Koirala Institute
of Health Sciences with the aim to find out association of different lipid parameters and Body Mass
Index (BMI) among newly diagnosed hypertension without any medications in Eastern Nepal.
80 hypertensive patients fulfilling JNC-7 criteria and 80 healthy controls were enrolled in this study.
Lipid parameters (TC, TG, LDLc, VLDLc, HDLc) were estimated by Enzymatic Colorimetric test.
Quetlet’s formula was used to calculate BMI.
Results were analyzed with student’s ‘t’ test and Pearson correlation analysis. Mean age of patients
and controls were 36.30 ± 7.73 yrs & 32.13 ± 7.21 yrs respectively. There was significant increase in
different lipid parameters namely TC (170.18 22.53 vs 145.23 21.13,P<0.005), TG (146.60 53.87 vs
119.77 35.61, P<0.005), LDLc (100.71 23.74 vs 79.25 20.10,P<0.05) and VLDLc (29.32 1077 vs 23.92
7.12, P<0.05) in patients as compared to the healthy controls. However there was no any significant
difference in HDLc value. Pearson correlation analysis shows positive correlation of BMI with all
the four lipid parameters even though it was not statistically significant. Thus this study shows direct
association of BMI, dyslipidemia in hypertensive patients of the Eastern Nepal.

Key Words: Dyslipidemia, Hypertension Body Mass Index, Hypertension.