Study of Acid-Base Disorders and Biochemical Findings of Patients in a Tertiary Care Hospital: A Descriptive Cross-sectional Study

  • Rupesh Kumar Shreewastav Nobel Medical College Teaching Hospital, Biratnagar, Nepal.
  • Krishna Prasad Jaishi Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.
  • Madan Raj Pandey Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.
  • Ganesh Prasad Singh Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.
  • Arambam Giridhari Singh Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.
Keywords: Acidosis, Alkalosis, pH, critical illness

Abstract

Introduction: Acid base disorder is a condition characterized by alteration in blood pH by the
imbalance between the components of blood leading to a life threatening situation. The main aim
of this study was to find the prevalence of acid-base disorders and biochemical findings of such
disorders in patients in a tertairy care hospital.


Methods: This descriptive cross-sectional study was conducted in Nobel Medical College Teaching
Hospital from 1st September, 2018 to 31st August, 2019. Ethical apporoval was taken from Institutional
Review Committee. All the patients presented to emergency department, intensive care units and
wards were included during the study period. Data were entered and calculations were done in
Microsoft Excel, point estimate at 95% Confidence Interval was calculated along with frequency and
proportion for binary data.


Results: Out of arterial blood gas analysis of 1144 patients, the prevalence of acid base disorders
was 718 (62.76%) at 95% Confidence Interval (59.96-65.56%). Simple and mixed acid base disorders
were observed in 332 (46.24%) and 386 (53.76%) patients respectively. Respiratory alkalosis was most
common among 134 (40.36%) cases in simple acid base disorder whereas metabolic acidosis and
respiratory alkalosis was most common among 204 (52.85%) in mixed acid base disorder. All types
of disorders were observed more in elderly people (41-60 and >60 age group) than other age groups.


Conclusions: Acid base disorder was found to be more common in very ill patients in emergency and
intensive care units compared to similar studies. Mixed acid base disorder was the most common
with male and elderly patients in predominance.

Published
2019-12-31
How to Cite
Shreewastav, R. K., Jaishi, K. P., Pandey, M. R., Singh, G. P., & Singh, A. G. (2019). Study of Acid-Base Disorders and Biochemical Findings of Patients in a Tertiary Care Hospital: A Descriptive Cross-sectional Study. Journal of Nepal Medical Association, 57(220). https://doi.org/10.31729/jnma.4736
Section
Original Article