Blood-based Biomarkers for Early Diagnosis of Lung Cancer: A Review Article

  • Narayani Maharjan Department of Clinical Laboratory Medicine and Centerfor Gene Diagnosis, Zhongnan Hospital of Wuhan University http://orcid.org/0000-0002-8930-7409
  • Niresh Thapa Karnali Academy of Health Sciences, Jumla, Nepal
  • Jiancheng Tu Department of Clinical Laboratory Medicine and Center for Gene Diagnosis, Zhongnan Hospital of Wuhan University, P. R. China
Keywords: biomarkers; blood; early diagnosis; lung cancer; microRNAs

Abstract

Lung cancer is the severe leading cause of cancer-related mortality worldwide. Early detection of lung cancer can significantly increase their survival rate. However, conventional lung cancer screening methods such as sputum cytology, chest X-rays, low-dose computed tomography, positron emission tomography, and magnetic resonance imaging, are radiational, and also expensive methods. Similarly, lung tumor tissue as invasive and difficult to obtain and potentially risky procedures, there is the immediate need of non-invasive, novel sensitive and reliable blood-based tumor markers which now has become an important area on research. This review will mainly focus on recently identified circulating biomarkers: circulating tumor cells, circulating tumor deoxyribonucleic acid, tumor-derived exosomes, circulating ribonucleic acid and micro ribonucleic acid, and tumoreducated platelets which may enable earlier diagnosis of lung cancer and their application in clinical
practices.

Published
2020-07-31
How to Cite
Maharjan, N., Thapa, N., & Tu, J. (2020). Blood-based Biomarkers for Early Diagnosis of Lung Cancer: A Review Article. Journal of Nepal Medical Association, 58(227). https://doi.org/10.31729/jnma.5023