Extensive Mucosal Erosion and Sloughing of Tongue: A Hitherto Unknown Complication of Topical Clotrimazole Preparation

  • Mainak Dutta Department of Otorhinolaryngology and Head-Neck Surgery, R. G. Kar Medical College and Hospital, Khudiram Bose Sarani, Kolkata, West Bengal
  • Soumya Ghatak Department of Otorhinolaryngology and Head-Neck Surgery, R. G. Kar Medical College and Hospital, Khudiram Bose Sarani, Kolkata, West Bengal
  • Gautam Biswas Department of Otorhinolaryngology and Head-Neck Surgery, Murshidabad Medical College and Hospital, Berhampore, Murshidabad, West Bengal
  • Ramanuj Sinha Department of Otorhinolaryngology and Head-Neck Surgery, R. G. Kar Medical College and Hospital, Khudiram Bose Sarani, Kolkata, West Bengal

Abstract

Clotrimazole, a broad-spectrum imidazole antimycotic, is a widely-used prescription as well as an over-the-counter drug for treatment of mucosal (oral, vulvovaginal) candidiasis and dermatophytes. An extremely safe and well-tolerated drug, its safety profile has been well-explored in researches and trials. The commonest complaints are almost always non-serious-pruritus, rashes, paraesthesia (stinging/burning sensation) and erythema on topical applications, and nausea, vomiting, unpleasant taste sensation and elevated liver enzymes on oral preparations (troches). However, mucosal ulceration on topical clotrimazole preparation has not been reported in literature before. We present here the first documentation of extensive bilateral erosions and
necrosis of tongue involving the mucosa, submucosa and musculature on application of one percent weight/volume clotrimazole mouth paint in a 27-year-old immunocompetent woman who presented with oral candidiasis.

Keywords: extensive bilateral ulceration and necrosis; oral candidiasis; side effect; topical clotrimazole.

Published
2013-03-31
How to Cite
Dutta, M., Ghatak, S., Biswas, G., & Sinha, R. (2013). Extensive Mucosal Erosion and Sloughing of Tongue: A Hitherto Unknown Complication of Topical Clotrimazole Preparation. Journal of Nepal Medical Association, 52(189), 277-280. https://doi.org/10.31729/jnma.585
Section
Case Reports