Pralidoxime in organophosphorus poisoning

Authors

  • N R Simkhada Department of Clinical Pharmacology, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu
  • KK Kafle Department of Clinical Pharmacology, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
  • PN Prasad Department of General Practice and Emergency, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal

DOI:

https://doi.org/10.31729/jnma.62

Abstract

INTRODUCTION:

Pralidoxime are enzyme reactivator that are known to reactivate the phosphorylated acetylcholinesterase by binding to the organophosphorus molecule. The use of oximes in acute organophosphorus poisoning has been a controversial subjects for over two decades. This study was conducted with the objective to find out the estimation of serum cholinesterase and use of pralidoxime in organophosphorus poisoning.

METHODS:

A prospective analysis of all organophosphorus poisoning cases presented at the Emergency Department, Tribhuvan University Teaching Hospital for seven months was done.

RESULTS:

Out of 26 cases about 60% of poisoning cases were monitored for pseudocholinesterase level. About 50% of them had pseudocholinesterase level within normal limit and 20% had less than 10% of normal value. Only 33% cases with pseudocholinesterase level less than 10% were treated with pralidoxime.

CONCLUSIONS:

The initial dose of Pralidoxime used was 1 gm followed by maintenance dose of 500mg 6 hourly, the doses prescribed were less than WHO recommended doses.

 Keywords: cholinesterase, emergency, organophosphorus,poisoning, Pralidoxime.  

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Published

2010-12-31

How to Cite

Simkhada, N. R., Kafle, K., & Prasad, P. (2010). Pralidoxime in organophosphorus poisoning. Journal of Nepal Medical Association, 50(180). https://doi.org/10.31729/jnma.62

Issue

Vol. 50 No. 180 (2010)

Section

Original Article

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