@article{Khadka_Tiwari_Gautam_Timalsina_Pathak_Kharel_Sharma_Acharya_2018, title={Correlates of Selected Biochemical Markers of Bone turnover among Post-Menopausal Women}, volume={56}, url={https://www.jnma.com.np/jnma/index.php/jnma/article/view/3604}, DOI={10.31729/jnma.3604}, abstractNote={<p><strong>Introduction:</strong> Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important of research in low income country like Nepal. </p> <p><strong>Methods:</strong> A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20.</p> <p><strong>Results:</strong> Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01).</p> <p><strong>Conclusions:</strong> Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health.</p>}, number={212}, journal={Journal of Nepal Medical Association}, author={Khadka, Bikram and Tiwari, Mohan Lal and Gautam, Ravi and Timalsina, Binod and Pathak, Nandu Prasad and Kharel, Krishna and Sharma, Shanta and Acharya, Dilaram}, year={2018}, month={Aug.}, pages={754–758} }