TY - JOUR AU - Zhang, Jing AU - Wang, Yan AU - Feng, Jing AU - Sun, Xin PY - 2013/07/01 Y2 - 2024/03/29 TI - Sleep Induced Hypoxemia in Chronic Obstructive Pulmonary Disease JF - Journal of Nepal Medical Association JA - J Nepal Med Assoc VL - 52 IS - 191 SE - Review Article DO - 10.31729/jnma.2285 UR - https://www.jnma.com.np/jnma/index.php/jnma/article/view/2285 SP - AB - <p>Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality worldwide.<br />Sleep-induced hypoxemia is defined as “an SpO2 (oxyhemoglobin saturation) during sleep of &lt;<br />90% for more than five minutes with a nadir of at least 85%” or “&gt; 30% of total sleep time with an<br />SpO2 of &lt; 90%” in subject with a baseline awake SpO2 of ≥ 90%. Patients with moderate or severe<br />COPD run a high risk of developing SIH mainly because of alveolar hypoventilation and ventilationperfusion<br />mismatch. Compared to their non-SIH brethren, SIH COPD patients have greater degrees<br />of pulmonary hypertension and cor pulmonale, require more frequent hospitalizations, and sustain<br />higher mortality rates. And the necessity of treatment of isolated SIH in COPD has been debated<br />for years. In this mini review, the definition, reasons, prevalence, clinical significance and treatment<br />approaches of SIH in COPD are summarized.<br />_______________________________________________________________________________________<br />Keywords: chronic obstructive pulmonary disease; polysomnography; rapid eye movement;<br />sleep-induced hypoxemia.</p> ER -