Low Cluster of Differentiation 4+ T Cell Count in People Living with HIV/AIDS Undergoing Antiretroviral Therapy Visiting a Reference Laboratory: A Descriptive Cross-sectional Study

Authors

  • Samikshya Kandel Nepal Academy of Science and Technology, Khumaltar, Lalitpur
  • Sundar Khadka National Public Health Laboratory, Teku, Kathmandu, Nepal
  • Mahesh Lamsal Department of Biotechnology, Tribhuwan University, Kirtipur, Kathmnadu, Nepal
  • Bimlesh Jha National Public Health Laboratory, Teku, Kathmandu, Nepal
  • Sunil Paudyal National Public Health Laboratory, Teku, Kathmandu, Nepal
  • Swotantra Gautam B. P. Koirala Institute of Health Sciences, Dharan, Nepal
  • Sagar Poudel All India Institute of Medical Sciences, New Delhi, India
  • Mukunda Sharma National Public Health Laboratory, Teku, Kathmandu, Nepal
  • Jeena Amatya St. Xavier’s College, Maitighar, Kathmandu, Nepal

DOI:

https://doi.org/10.31729/jnma.6062

Keywords:

acquired immunodeficiency syndrome, cluster of differentiation 4 lymphocyte count, human immunodeficiency virus

Abstract

Introduction: Human Immunodeficiency Virus is a lentivirus that causes human immunodeficiency virus infection and over time, acquired immunodeficiency syndrome. Cluster of Differentiation 4+ T cell count of people living with this infection play a vital role to determine infection progression and necessary treatment changes. This study was conducted to find out the prevalence of low Cluster of Differentiation 4+ T Cell Count in the People Living with human immunodeficiency virus/ acquired immunodeficiency syndrome.

Methods: A descriptive cross-sectional study was conducted between June to August 2018 in the Human Immunodeficiency virus and Hepatitis Reference Unit of National Public Health Laboratory, Ministry of Health and Population Teku. Ethical approval was taken (Reference Number 2912) and a total of 550 seropositive cases of Human Immunodeficiency Virus-1 undergoing antiretroviral therapy were studied. Convenient sampling technique was used. Data was analysed by Statistical Package for the Social Sciences.

Results: Seventeen (3.1%) of patients had Cluster of Differentiation 4+ T cell counts below 100 cells/mm3 of blood. The mean Cluster of Differentiation 4+ T cell count was 509.3 cells/mm3 of blood. Of the total samples, 280 (50.9%) were males, 268 (48.7%) were females, and the rest 2 (0.4%) were of other gender.

Conclusions: Majority of people living with human immunodeficiency virus/ acquired immunodeficiency syndrome were found immune-competent.

Additional Files

Published

2021-05-25

How to Cite

Kandel, S., Khadka, S. . . . ., Lamsal, M. ., Jha, B. . . . . . . . ., Paudyal , S., Gautam, . S. . . . ., Poudel, S. . ., Sharma, M. . ., & Amatya, J. (2021). Low Cluster of Differentiation 4+ T Cell Count in People Living with HIV/AIDS Undergoing Antiretroviral Therapy Visiting a Reference Laboratory: A Descriptive Cross-sectional Study. Journal of Nepal Medical Association, 59(237), 486–489. https://doi.org/10.31729/jnma.6062

Issue

Vol. 59 No. 237 (2021): JNMA: Published Monthly

Section

Original Article

License

Copyright (c) 2021 Samikshya Kandel, Sundar Khadka, Mahesh Lamsal, Bimlesh Jha, Sunil Paudyal , Dr. Swotantra Gautam, Dr. Sagar Poudel, Dr.Mukunda Sharma , Jeena Amatya

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