Tofacitinib as an Adjunct Immunomodulator for Treatment of a Patient with Severe COVID-19: A Case Report

Authors

  • Gentle Sunder Shrestha Department of Anaesthesiology, Tribhuvan University Teaching Hospital, Kathmandu
  • Bidesh Bista Department of Internal Medicine, Civil Service Hospital of Nepal, Kathmandu, Nepal
  • Ashesh Dhungana Department of Internal Medicine, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal
  • Nimesh Poudel Department of Internal Medicine, Kathmandu Medical College and Teaching Hospital, Kathmandu, Nepal
  • Shraddha Bhattarai Department of Critical Care Medicine, Alka Hospital Pvt. Ltd, Lalitpur, Nepal
  • Manjit Shrestha Department of Critical Care Medicine, Alka Hospital Pvt. Ltd, Lalitpur, Nepal
  • Sandip Bhandari Department of Anaesthesiology, Shahid Gangalal National Heart Centre, Kathmandu, Nepal
  • Binit Vaidya Department of Rheumatology, National Center for Rheumatic Diseases, Kathmandu, Nepal

DOI:

https://doi.org/10.31729/jnma.6680

Keywords:

COVID-19, dexamethasone, immunomodulation

Abstract

Severe coronavirus disease 2019 can be associated with progressive respiratory failure. In addition to respiratory support and other supportive care, use of corticosteroids has shown to improve outcome. Despite the use of steroids, a significant proportion of patients progressively worsen. Adjunct immunomodulators have been studied in addition to steroids in these patients. Here we present a successful use of tofacitinib, a Janus Kinase inhibitor, in conjunction with dexamethasone for a patient with rapid worsening of respiratory status and with high level of serum inflammatory biomarkers.

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Published

2021-07-01

How to Cite

Shrestha, G. S., Bista, B., Dhungana, A., Poudel, N., Bhattarai, S., Shrestha, M., Bhandari, S., & Vaidya, B. (2021). Tofacitinib as an Adjunct Immunomodulator for Treatment of a Patient with Severe COVID-19: A Case Report. Journal of Nepal Medical Association, 59(238), 593–596. https://doi.org/10.31729/jnma.6680

Issue

Vol. 59 No. 238 (2021): JNMA: Published Monthly

Section

Case Reports

License

Copyright (c) 2021 Gentle Sunder Shrestha, Bidesh Bista, Ashesh Dhungana, Nimesh Poudel, Shraddha Bhattarai, Manjit Shrestha, Sandip Bhandari, Binit Vaidya

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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