GASTRIC ADENOCARCINOMA AND HELICOBACTER PYLORI INFECTION
DOI:
https://doi.org/10.31729/jnma.681Abstract
Gastric adenocarcinoma is of major importance worldwide as a cause of death from
malignant disease. It is the commonest malignant tumor in T.U. Teaching Hospital.
Helicobacter pylori infection is an important risk factor for the development of gastric
cancer. This prospective study was carried out to correlate H. pylori infection with
gastric adenocarcinoma. This study was done from January 1999 to January 2000;
included 38 cases of gastric adenocarcinomas of which 28 (73.69%) cases were tubular
type; 6 (15.79%) cases were signet-ring cell type; 2 (5.26%) cases were papillary type
and 2 (5.26%) cases were mucinous type. Gastric adenocarcinomas were more common
in male (73.68%) and after the age of 50 years. Giemsa staining revealed H. pylori in
30 cases (78.95%) of adenocarcinomas; whereas H. pylori seropositivity (IgG) was
found in 29 (76.31%) cases. H. pylori were histologically detected in 88.3% cases of
resected specimens and in 71.4% cases of endoscopic gastric biopsies. Both histological
method and serological test showed positivity for H. pylori in 65.78% cases. Thus, H.
pylori infection is associated with gastric carcinognesis
Key Words: Gastric adenocarcinoma, Helicobacter pylori, Giemsa stain.
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