Breast Arterial Calcifications on Mammography among Patients Attending the Radiology Department in a Tertiary Care Centre: A Descriptive Cross-sectional Study

Authors

  • Anamika Jha Department of Radiology, Tribhuvan University Teaching Hospital, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal
  • Anugya Sah Department of Radiology, Tribhuvan University Teaching Hospital, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal
  • Birendra Raj Joshi Department of Radiology, Tribhuvan University Teaching Hospital, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal https://orcid.org/0000-0002-0338-5810
  • Benu Lohani Department of Radiology, Tribhuvan University Teaching Hospital, Maharajgunj Medical Campus, Maharajgunj, Kathmandu, Nepal

DOI:

https://doi.org/10.31729/jnma.6922

Keywords:

atherosclerosis, calcification, mammography

Abstract

Introduction: Breast arterial calcifications are common mammographic findings which are associated with coronary artery disease. The aim of this study was to find the prevalence of breast arterial calcifications in women presenting for mammography in a tertiary care centre.

Methods: This descriptive cross-sectional study was performed in the Department of Radiology, in a tertiary care hospital after taking ethical clearance, Reference number 352(6-11)E-2, 077/078, data was collected from Syngovia database from March-June 2021 which included 1614 mammograms. Convenience sampling was done and mammograms evaluated for presence of vascular or non-vascular calcification. Further, vascular calcification was graded. Data was entered in Statistical Package for Social Sciences version 25. Point estimate at 95% Confidence Interval was done, and frequency and proportion were calculated.

Results: The prevalence of breast arterial calcification was 188 (11.6%) at 95% Confidence Interval (10.03-13.2). The mean age of women included in this study was 48.42±9.55 years with the largest number of patients in the age group 40-49 years, 682 (42.3%), and least in the age group 80-89 years, 3 (0.2%). All patients in the age group 80-89 years, 3 (100%) had vascular calcifications followed by 70-79 years group, 22 (57.5%) and none in patients younger than 30 years.

Conclusions: We found an increase in the number and grade of vascular calcifications in breasts with the patient's age. When present breast arterial calcifications must be mentioned in mammogram report. Identification of such calcifications on mammogram should prompt further screening for atherosclerotic disease.

References

Giri M, Giri M, Thapa RJ, Upreti B, Pariyar B. Breast Cancer in Nepal: Current status and future directions. Biomedical Rep. 2018; 8: 325-9. DOI: 10.3892/br.2018.1057 link

Kelly BS, ScanlON E, Heneghan H, Redmond CE, Healy GM, Mc Dermott E, Heffernan EJ, Prichard R, Mc Nally S. Breast Arterial Calcification on screening mammography can predict significant Coronary Artery Disease in women. Clin Imaging. 2018 May-Jun;49:48-53. DOI: 10.1016/j.clinimag.2017.10.021. PMID: 29127877. link

Akinola RA, Ogbera OA et al. Mammograms and breast arterial calcifications: looking beyond breast cancer: a preliminary report. BMC Res Notes 2011; 4:207. DOI: https://doi.org/10.1186/1756-0500-4-207 link

Moshyedi AC, Puthawala AH, Kurland RJ, O'Leary DH. Breast arterial calcification: Association with coronary artery disease. Work in progress. Radiology. 1995;194: 181-83. DOI: 10.1148/radiology.194.1.7997548 link

Ali, E.A., Fouad, H., Razek, N.A. et al. Evaluation of mammography detected breast arterial calcifications as a predictor of coronary cardiac risk. Egypt J Radiol Nucl Med 2019 ;50: 81. DOI: https://doi.org/10.1186/s43055-019-0095-7 link

Loberant N, Salamon V, Carmi N, Chernihovsky A. Prevalence and Degree of Breast Arterial Calcifications on Mammography: A Cross-sectional Analysis. J Clin Imaging Sci. 2013;3:36. DOI: 10.4103/2156-7514.119013. link

Mostafavi L, Marfori W, Arellano C, Tognolini A, Speier W, Adibi A, Ruehm SG. Prevalence of coronary artery disease evaluated by coronary CT angiography in women with mammographically detected breast arterial calcifications. PloS one. 2015 Apr 9;10(4). DOI: 10.1371/journal.pone.0122289. link

Kim H, Greenberg JS, Javitt MC. Breast calcifications due to Mönckeberg medial calcific sclerosis. Radiographics. 1999;19(5): 1401–3. DOI: 10.1148/radiographics.19.5.g99se221401. link

Pecchi A, Rossi R, Coppi F, Ligabue G, Modena MG, Romagnoli R. Association of breast arterial calcifications detected by mammography and coronary artery calcifications quantified by multislice CT in a population of post-menopausal women. Radiol Med. 2003;106(4): 305–12. PMID: 14612822. link

Rotter MA, Schnatz PF, Currier AA Jr, O'Sullivan DM. Breast arterial calcifications (BACs) found on screening mammography and their association with cardiovascular disease. Menopause. 2008 Mar-Apr;15(2):276-81. DOI: 10.1097/gme.0b013e3181405d0a link

. McLenachan, F. Camilleri, M. Smith, D.E. Newby, M.C. Williams. Breast arterial calcification on mammography and risk of coronary artery disease: a SCOT-HEART sub-study. Clinical Radiology 2019;74(6): 421-8. DOI: 10.1016/j.crad.2019.01.014 link

Maas AH, van der Schouw YT, Beijerinck D, Deurenberg JJ, Mali WP, van der Graaf Y. Arterial calcifications seen on mammograms: cardiovascular risk factors, pregnancy, and lactation. Radiology. 2006 Jul;240(1):33-8. DOI: 10.1148/radiol.2401050170. link

Reddy J, Son H, Smith SJ, Paultre F, Mosca L. Prevalence of breast arterial calcifications in an ethnically diverse population of women. Ann Epidemiol. 2005 May;15(5):344-50. DOI: 10.1016/j.annepidem.2004.11.006. link

Margolies LR, Yip R, Hwang E, Oudsema RH, Subramaniam VR, Hecht H, Narula J. Breast Arterial Calcification in the Mammogram Report: The Patient Perspective. American Journal of Roentgenology 2019; 212(1): 209-14. DOI: 10.2214/AJR.18.20171. link

Fiuza Ferreira EM, Szeinfield J, Faintuch S: Correlation between intramammary arterial calcifications and CAD. Acta Radiol. 2007; 14 (2): 144-150. DOI: 10.1016/j.acra.2006.10.017. link

Downloads

Published

2021-09-11

How to Cite

Jha, A., Sah, A., Joshi, B. R., & Lohani, B. (2021). Breast Arterial Calcifications on Mammography among Patients Attending the Radiology Department in a Tertiary Care Centre: A Descriptive Cross-sectional Study. Journal of Nepal Medical Association, 59(241), 844–847. https://doi.org/10.31729/jnma.6922